The Sol Goldman Pancreatic Cancer Research Center

Selected References by Hopkins' Pancreas Cancer Researchers

  1. Matsen SL, Yeo CJ, Hruban RH, Choti MA. Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review. J Gastrointest Surg. 2005 Feb;9(2):270-9. abstract
  2. Sato N, Parker AR, Fukushima N, Miyagi Y, Iacobuzio-Donahue CA, Eshleman JR, Goggins M. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene. 2005 Jan 27;24(5):850-8. abstract
  3. Sato N, Matsubayashi H, Fukushima N, Goggins M. The Chemokine Receptor CXCR4 is Regulated by DNA Methylation in Pancreatic Cancer. Cancer Biol Ther. 2005 Jan 15;4(1) abstract
  4. Hustinx SR, Hruban RH, Leoni LM, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Brown PN, Argani P, Asfaq R, Fukushima N, Goggins M, Kern SE, Maitra A. Homozygous Deletion of the MTAP Gene In Invasive Adenocarcinoma of the Pancreas and in Periampullary Cancer: A Potential New Target for Therapy. Cancer Biol Ther. 2005 Jan 15;4(1). abstract
  5. Matsubayashi H, Sato N, Brune K, Blackford AL, Hruban RH, Canto M, Yeo CJ, Goggins M. Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):573-83. abstract
  6. Cao D, Maitra A, Saavedra JA, Klimstra DS, Adsay NV, Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways. Mod Pathol. 2005 Jan 14; abstract
  7. Henke RT, Maitra A, Paik S, Wellstein A. Gene expression analysis in sections and tissue microarrays of archival tissues by mRNA in situ hybridization. Histol Histopathol. 2005 Jan;20(1):225-37. abstract
  8. Rosty C, Goggins M. Identification of differentially expressed proteins in pancreatic cancer using a global proteomic approach. Methods Mol Med. 2004;103:189-98. abstract
  9. Curtis CD, Goggins M. DNA methylation analysis in human cancer. Methods Mol Med. 2004;103:123-36. abstract
  10. Hruban RH, Wilentz RE, Maitra A. Identification and analysis of precursors to invasive pancreatic cancer. Methods Mol Med. 2004;103:1-14. abstract
  11. Walter K, Eshleman J, Goggins M. Xenografting and harvesting human ductal pancreatic adenocarcinomas for DNA analysis. Methods Mol Med. 2004;103:103-12. abstract
  12. Xin W, Yun KJ, Ricci F, Zahurak M, Qiu W, Su GH, Yeo CJ, Hruban RH, Kern SE, Iacobuzio-Donahue CA. MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res. 2004 Dec 15;10(24):8516-20. abstract
  13. Amador ML, Oppenheimer D, Perea S, Maitra A, Cusati G, Iacobuzio-Donahue C, Baker SD, Ashfaq R, Takimoto C, Forastiere A, Hidalgo M. An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. Cancer Res. 2004 Dec 15;64(24):9139-43. abstract
  14. Rogers CD, Couch FJ, Brune K, Martin ST, Philips J, Murphy KM, Petersen G, Yeo CJ, Hruban RH, Goggins M. Genetics of the FANCA gene in familial pancreatic cancer. J Med Genet. 2004 Dec;41(12):e126. No abstract available.
  15. Fukushima N, Sato N, Prasad N, Leach SD, Hruban RH, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004 Dec 2;23(56):9042-51. abstract
  16. Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, Iacobuzio-Donahue C, Cameron JL, Yeo CJ, Kern SE, Goggins M, Mollenhauer J, Pandey A, Hruban RH. Differentially Expressed Genes in Pancreatic Ductal Adenocarcinomas Identified Through Serial Analysis of Gene Expression. Cancer Biol Ther. 2004 Dec 14;3(12). abstract
  17. Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res. 2004 Sep-Oct;3(5):1042-55. abstract
  18. Cao D, Hustinx SR, Sui G, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CJ, Kern SE, Goggins M, Pandey A, Hruban RH. Identification of Novel Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas through a Bioinformatics Analysis of Expressed Sequence Tags. Cancer Biol Ther. 2004 Nov 12;3(11). abstract
  19. Kawamoto S, Siegelman SS, Hruban RH, Fishman EK. Lymphoplasmacytic sclerosing pancreatitis with obstructive jaundice: CT and pathology features. AJR Am J Roentgenol. 2004 Oct;183(4):915-21. abstract
  20. Brody JR, Calhoun ES, Gallmeier E, Creavalle TD, Kern SE. Ultra-fast high-resolution agarose electrophoresis of DNA and RNA using low-molarity conductive media. Biotechniques. 2004 Oct;37(4):598, 600, 602. abstract
  21. Matsubayashi H, Fujiwara S, Kobayashi Y, Iiri T, Mitra A, Goggins M, Hruban RH, Moriyasu F. A small cell carcinoma of the pancreas with a high level of serum ProGRP. J Clin Gastroenterol. 2004 Oct;38(9):834-5. No abstract available.
  22. Sato N, Maehara N, Goggins M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 2004 Oct 1;64(19):6950-6. abstract
  23. Brody JR, Kern SE. History and principles of conductive media for standard DNA electrophoresis. Anal Biochem. 2004 Oct 1;333(1):1-13. abstract
  24. Koopmann J, Thuluvath PJ, Zahurak ML, Kristiansen TZ, Pandey A, Schulick R, Argani P, Hidalgo M, Iacobelli S, Goggins M, Maitra A. Mac-2-binding protein is a diagnostic marker for biliary tract carcinoma. Cancer. 2004 Oct 1;101(7):1609-15. abstract
  25. Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ, Maitra A. Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6152-8. abstract
  26. Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A, Riegel AT. Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6134-42. abstract
  27. Thomas AM, Santarsiero LM, Lutz ER, Armstrong TD, Chen YC, Huang LQ, Laheru DA, Goggins M, Hruban RH, Jaffee EM. Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med. 2004 Aug 2;200(3):297-306. abstract
  28. van der Heijden MS, Brody JR, Gallmeier E, Cunningham SC, Dezentje DA, Shen D, Hruban RH, Kern SE. Functional defects in the fanconi anemia pathway in pancreatic cancer cells. Am J Pathol. 2004 Aug;165(2):651-7. abstract
  29. Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, Biankin SA, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, Shimizu M, Yonezawa S. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol. 2004 Aug;28(8):977-87. abstract
  30. Canto MI, Goggins M, Yeo CJ, Griffin C, Axilbund JE, Brune K, Ali SZ, Jagannath S, Petersen GM, Fishman EK, Piantadosi S, Giardiello FM, Hruban RH. Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clin Gastroenterol Hepatol. 2004 Jul;2(7):606-21. abstract
  31. Adsay NV, Merati K, Basturk O, Iacobuzio-Donahue C, Levi E, Cheng JD, Sarkar FH, Hruban RH, Klimstra DS. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004 Jul;28(7):839-48. abstract
  32. Van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M. Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther. 2004 Jul;3(7):651-6. abstract
  33. Van Der Heijden MS, Brody JR, Kern SE. Functional screen of the fanconi anemia pathway in cancer cells by fancd2 immunoblot. Cancer Biol Ther. 2004 Jun;3(6):534-7. abstract
  34. Koopmann J, Goggins M, Hruban RH. Case 7-2004: hereditary melanoma and pancreatic cancer. N Engl J Med. 2004 Jun 17;350(25):2623-4; author reply 2623-4. No abstract available.
  35. Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg. 2004 Jun;239(6):788-97; discussion 797-9. abstract
  36. Maitra A, Cohen Y, Gillespie SE, Mambo E, Fukushima N, Hoque MO, Shah N, Goggins M, Califano J, Sidransky D, Chakravarti A. The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res. 2004 May;14(5):812-9. abstract
  37. Meeker AK, Hicks JL, Iacobuzio-Donahue CA, Montgomery EA, Westra WH, Chan TY, Ronnett BM, De Marzo AM. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004 May 15;10(10):3317-26. abstract
  38. Takaori K, Hruban RH, Maitra A, Tanigawa N. Pancreatic intraepithelial neoplasia. Pancreas. 2004 Apr;28(3):257-62. abstract
  39. Koopmann J, Buckhaults P, Brown DA, Zahurak ML, Sato N, Fukushima N, Sokoll LJ, Chan DW, Yeo CJ, Hruban RH, Breit SN, Kinzler KW, Vogelstein B, Goggins M. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res. 2004 Apr 1;10(7):2386-92. abstract
  40. Klein AP, Brune KA, Petersen GM, Goggins M, Tersmette AC, Offerhaus GJ, Griffin C, Cameron JL, Yeo CJ, Kern S, Hruban RH. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004 Apr 1;64(7):2634-8. abstract
  41. House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD, Hruban RH, Horton KM, Fishman EK, Lillemoe KD. Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg. 2004 Mar-Apr;8(3):280-8. abstract
  42. Choti MA. Adjuvant therapy for pancreatic cancer--the debate continues. N Engl J Med. 2004 Mar 18;350(12):1249-51. Full Text
  43. Swierczynski SL, Maitra A, Abraham SC, Iacobuzio-Donahue CA, Ashfaq R, Cameron JL, Schulick RD, Yeo CJ, Rahman A, Hinkle DA, Hruban RH, Argani P. Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Hum Pathol. 2004 Mar;35(3):357-66. abstract
  44. Iacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, Kern SE. Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res. 2004 Mar 1;10(5):1597-604. abstract
  45. Koopmann J, Fedarko NS, Jain A, Maitra A, Iacobuzio-Donahue C, Rahman A, Hruban RH, Yeo CJ, Goggins M. Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):487-91. abstract
  46. Sato N, Fukushima N, Maitra A, Iacobuzio-Donahue CA, van Heek NT, Cameron JL, Yeo CJ, Hruban RH, Goggins M. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol. 2004 Mar;164(3):903-14. abstract
  47. Iacobuzio-Donahue CA, van der Heijden MS, Baumgartner MR, Troup WJ, Romm JM, Doheny K, Pugh E, Yeo CJ, Goggins MG, Hruban RH, Kern SE. Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss. Cancer Res. 2004 Feb 1;64(3):871-5. abstract
  48. Nichols LS, Ashfaq R, Iacobuzio-Donahue CA. Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. Am J Clin Pathol. 2004 Feb;121(2):226-30. abstract
  49. Rogers CD, van der Heijden MS, Brune K, Yeo CJ, Hruban RH, Kern SE, Goggins M. The genetics of FANCC and FANCG in familial pancreatic cancer. Cancer Biol Ther. 2004 Feb;3(2):167-9. abstract
  50. Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec;4(6):437-50. abstract
  51. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res. 2003 Dec 15;63(24):8614-22. abstract
  52. Matsubayashi H, Fukushima N, Sato N, Brune K, Canto M, Yeo CJ, Hruban RH, Kern SE, Goggins M. Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. Cancer Biol Ther. 2003 Nov-Dec;2(6):652-5. abstract
  53. House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Cameron JL, Hruban RH, Maitra A, Yeo CJ. Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms. Surgery. 2003 Dec;134(6):902-8; discussion 909. abstract
  54. Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M. p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis. Am J Surg Pathol. 2003 Dec;27(12):1495-501. abstract
  55. Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ, Maitra A. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res. 2003 Nov 1;63(21):7032-7. abstract
  56. Rahman A, Maitra A, Ashfaq R, Yeo CJ, Cameron JL, Hansel DE. Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasms. Am J Clin Pathol. 2003 Nov;120(5):685-90. abstract
  57. Abraham SC, Cruz-Correa M, Argani P, Furth EE, Hruban RH, Boitnott JK. Diffuse lymphoplasmacytic chronic cholecystitis is highly specific for extrahepatic biliary tract disease but does not distinguish between primary and secondary sclerosing cholangiopathy. Am J Surg Pathol. 2003 Oct;27(10):1313-20. abstract
  58. Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003 Oct 23;425(6960):846-51. abstract
  59. Sato N, Maitra A, Fukushima N, van Heek NT, Matsubayashi H, Iacobuzio-Donahue CA, Rosty C, Goggins M. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 2003 Jul 15;63(14):4158-66. abstract
  60. Hansel DE, Rahman A, Hermans J, de Krijger RR, Ashfaq R, Yeo CJ, Cameron JL, Maitra A. Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression. Mod Pathol. 2003 Jul;16(7):652-9. abstract
  61. Hempen PM, Kurpad H, Calhoun ES, Abraham S, Kern SE. A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T. Hum Mutat. 2003 Apr;21(4):445. abstract
  62. Iacobuzio-Donahue CA, Maitra A, Olsen M, Lowe AW, Van Heek NT, Rosty C, Walter K, Sato N, Parker A, Ashfaq R, Jaffee E, Ryu B, Jones J, Eshleman JR, Yeo CJ, Cameron JL, Kern SE, Hruban RH, Brown PO, Goggins M. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol. 2003 Apr;162(4):1151-62. abstract
  63. Hansel DE, Kern SE, Hruban RH. Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet. 2003;4:237-56. abstract
  64. Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol. 2003 Oct;163(4):1255-60. abstract
  65. House MG, Herman JG, Guo MZ, Hooker CM, Schulick RD, Lillemoe KD, Cameron JL, Hruban RH, Maitra A, Yeo CJ. Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Ann Surg. 2003 Sep;238(3):423-31; discussion 431-2. abstract
  66. Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, Yeo CJ, Hruban RH. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003 Sep;16(9):902-12. abstract
  67. McCarthy DM, Maitra A, Argani P, Rader AE, Faigel DO, Van Heek NT, Hruban RH, Wilentz RE. Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases. Appl Immunohistochem Mol Morphol. 2003 Sep;11(3):238-43. abstract
  68. Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH, Goggins M. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene. 2003 Aug 7;22(32):5021-30. abstract
  69. Montgomery E, Wilentz RE, Argani P, Fisher C, Hruban RH, Kern SE, Lengauer C. Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies. Cancer Biol Ther. 2003 May-Jun;2(3):248-52. abstract
  70. Buckhaults P, Zhang Z, Chen YC, Wang TL, St Croix B, Saha S, Bardelli A, Morin PJ, Polyak K, Hruban RH, Velculescu VE, Shih IeM. Identifying tumor origin using a gene expression-based classification map. Cancer Res. 2003 Jul 15;63(14):4144-9. abstract
  71. Fukushima N, Sato N, Sahin F, Su GH, Hruban RH, Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer. 2003 Jul 21;89(2):338-43. abstract
  72. Sahin F, Maitra A, Argani P, Sato N, Maehara N, Montgomery E, Goggins M, Hruban RH, Su GH. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol. 2003 Jul;16(7):686-91. abstract
  73. Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 003 Jun;3(6):565-76. abstract
  74. Sato N, Fukushima N, Maitra A, Matsubayashi H, Yeo CJ, Cameron JL, Hruban RH, Goggins M. Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res. 2003 Jul 1;63(13):3735-42. abstract
  75. Hardacre JM, Iacobuzio-Donahue CA, Sohn TA, Abraham SC, Yeo CJ, Lillemoe KD, Choti MA, Campbell KA, Schulick RD, Hruban RH, Cameron JL, Leach SD. Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis. Ann Surg. 2003 Jun;237(6):853-8; discussion 858-9. abstract
  76. van der Heijden MS, Yeo CJ, Hruban RH, Kern SE. Fanconi anemia gene mutations in young-onset pancreatic cancer. Cancer Res. 2003 May 15;63(10):2585-8. abstract
  77. Adsay NV, Merati K, Nassar H, Shia J, Sarkar F, Pierson CR, Cheng JD, Visscher DW, Hruban RH, Klimstra DS. Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Am J Surg Pathol. 2003 May;27(5):571-8. abstract
  78. Iacobuzio-Donahue CA, Hruban RH. Gene expression in neoplasms of the pancreas: applications to diagnostic pathology. Adv Anat Pathol. 2003 May;10(3):125-34. abstract
  79. Matsubayashi H, Sato N, Fukushima N, Yeo CJ, Walter KM, Brune K, Sahin F, Hruban RH, Goggins M. Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. Clin Cancer Res. 2003 Apr;9(4):1446-52. abstract
  80. Fukushima N, Walter KM, Uek T, Sato N, Matsubayashi H, Cameron JL, Hruban RH, Canto M, Yeo CJ, Goggins M. Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice. Cancer Biol Ther. 2003 Jan-Feb;2(1):78-83. abstract
  81. McCarthy DM, Hruban RH, Argani P, Howe JR, Conlon KC, Brennan MF, Zahurak M, Wilentz RE, Cameron JL, Yeo CJ, Kern SE, Klimstra DS. Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases. Mod Pathol. 2003 Mar;16(3):272-8. abstract
  82. Abraham SC, Cruz-Correa M, Argani P, Furth EE, Hruban RH, Boitnott JK. Lymphoplasmacytic chronic cholecystitis and biliary tract disease in patients with lymphoplasmacytic sclerosing pancreatitis. Am J Surg Pathol. 2003 Apr;27(4):441-51. abstract
  83. Hempen PM, Zhang L, Bansal RK, Iacobuzio-Donahue CA, Murphy KM, Maitra A, Vogelstein B, Whitehead RH, Markowitz SD, Willson JK, Yeo CJ, Hruban RH, Kern SE. Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers. Cancer Res. 2003 Mar 1;63(5):994-9. abstract
  84. Abraham SC, Leach S, Yeo CJ, Cameron JL, Murakata LA, Boitnott JK, Albores-Saavedra J, Hruban RH. Eosinophilic pancreatitis and increased eosinophils in the pancreas. Am J Surg Pathol. 2003 Mar;27(3):334-42. abstract
  85. Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R. Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet. 2003 Mar 1;12(5):575-82. abstract
  86. Petersen GM, Hruban RH. Familial pancreatic cancer: where are we in 2003? J Natl Cancer Inst. 2003 Feb 5;95(3):180-1. No abstract available.
  87. Nguyen TC, Sohn TA, Cameron JL, Lillemoe KD, Campbell KA, Coleman J, Sauter PK, Abrams RA, Hruban RH, Yeo CJ. Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors. J Gastrointest Surg. 2003 Jan;7(1):1-9; discussion 9-11. abstract
  88. Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK, Hruban RH. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all 'chronic pancreatitis'? Am J Surg Pathol. 2003 Jan;27(1):110-20. abstract
  89. Hruban RH, Wilentz RE. Pancreas. In N Weidner, RJ Cote, S Suster, LM Weiss, eds. Modern Surgical Pathology. WB Saunders Co, 2003.
  90. Kern SE, Hruban RH, Hidalgo M, Yeo CJ. An introduction to pancreatic adenocarcinoma genetics, pathology and therapy. Cancer Biol Ther. 2002 Nov-Dec;1(6):607-13. Review. abstract
  91. Rosty C, Goggins M. Early detection of pancreatic carcinoma. Hematol Oncol Clin North Am. 2002 Feb;16(1):37-52. abstract
  92. Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, Cameron JL, Wu TT, Hruban RH. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol. 2002 Apr;160(4):1361-9. abstract
  93. Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, Brennan M, Cameron JL, Klimstra DS. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol. 2002 Mar;160(3):953-62. abstract
  94. Adsay NV, Merati K, Andea A, Sarkar F, Hruban RH, Wilentz RE, Goggins M, Iocobuzio-Donahue C, Longnecker DS, Klimstra DS. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol. 2002 Oct;15(10):1087-95. abstract
  95. Yeo TP, Hruban RH, Leach SD, Wilentz RE, Sohn TA, Kern SE, Iacobuzio-Donahue CA, Maitra A, Goggins M, Canto MI, Abrams RA, Laheru D, Jaffee EM, Hidalgo M, Yeo CJ. Pancreatic cancer. Curr Probl Cancer. 2002 Jul-Aug;26(4):176-275. full article
  96. Tascilar M, van Rees BP, Sturm PD, Tytgat GN, Hruban RH, Goodman SN, Giardiello FM, Offerhaus GJ, Tersmette AC. Pancreatic cancer after remote peptic ulcer surgery. J Clin Pathol. 2002 May;55(5):340-5. abstract
  97. Ueki T, Walter KM, Skinner H, Jaffee E, Hruban RH, Goggins M. Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived. Oncogene. 2002 Mar 27;21(13):2114-7. abstract
  98. van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, Cameron JL, Offerhaus GJ, Hicks JL, Wilentz RE, Goggins MG, De Marzo AM, Hruban RH, Maitra A. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol. 2002 Nov;161(5):1541-7. abstract
  99. van Heek T, Rader AE, Offerhaus GJ, McCarthy DM, Goggins M, Hruban RH, Wilentz RE. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis. Am J Clin Pathol. 2002 May;117(5):755-65. abstract
  100. Fukushima N, Sato N, Ueki T, Rosty C, Walter KM, Wilentz RE, Yeo CJ, Hruban RH, Goggins M. Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. Am J Pathol. 2002 May;160(5):1573-81. abstract
  101. Hruban RH, Yeo CJ, Kern SE. Pancreatic cancer. In Scriver, Beaudet, Sly and Valle, eds. Molecular and Mendelian Basis of Inherited Disease. McGraw Hill, Inc., 8th Ed., Vol. 1, Chapter 50, 2002.

  102. Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, van Heek T, Ashfaq R, Meyer R, Walter K, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol. 2002 Apr;160(4):1239-49. abstract
  103. Iacobuzio-Donahue CA, Ryu B, Hruban RH, Kern SE. Exploring the host desmoplastic response to pancreatic carcinoma : gene expression of stromal and neoplastic cells at the site of primary invasion. Am J Pathol 160:91-9, 2002. abstract
  104. Jaffee EM, Hruban RH, Canto M, Kern SE. Focus on pancreas cancer. Cancer Cell. 2002 Jul;2(1):25-8. No abstract available.
  105. Klein AP, Beaty TH, Bailey-Wilson JE, Brune KA, Hruban RH, Petersen GM. Evidence for a major gene influencing risk of pancreatic cancer. Genet Epidemiol. 2002 Aug;23(2):133-49. abstract
  106. Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol. 2002 Apr;15(4):441-7. abstract
  107. Maitra A, Ashfaq R, Gunn CR, Rahman A, Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Wilentz RE. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. Am J Clin Pathol. 2002 Aug;118(2):194-201. abstract
  108. Maitra A, Iacobuzio-Donahue C, Rahman A, Sohn TA, Argani P, Meyer R, Yeo CJ, Cameron JL, Goggins M, Kern SE, Ashfaq R, Hruban RH, Wilentz RE. Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47. Am J Clin Pathol. 2002 Jul;118(1):52-9. abstract
  109. Movahedi-Lankarani S, Hruban RH, Westra WH, Klimstra DS. Primitive neuroectodermal tumors of the pancreas: a report of seven cases of a rare neoplasm. Am J Surg Pathol. 2002 Aug;26(8):1040-7. abstract
  110. Murphy KM, Brune KA, Griffin C, Sollenberger JE, Petersen GM, Bansal R, Hruban RH, Kern SE. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res. 2002 Jul 1;62(13):3789-93. abstract
  111. Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M. Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res. 2002 Mar 15;62(6):1868-75. abstract
  112. Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, Hruban RH, Goggins M. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 160:45-50, 2002. (abstract)
  113. Sato N, Ueki T, Fukushima N, Iacobuzio-Donahue CA, Yeo CJ, Cameron JL, Hruban RH, Goggins M. Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. Gastroenterology. 2002 Jul;123(1):365-72. abstract
  114. Seidel G, Zahurak M, Iacobuzio-Donahue C, Sohn TA, Adsay NV, Yeo CJ, Lillemoe KD, Cameron JL, Hruban RH, Wilentz RE. Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases. Am J Surg Pathol. 2002 Jan;26(1):56-63. abstract
  115. Swartz MJ, Batra SK, Varshney GC, Hollingsworth MA, Yeo CJ, Cameron JL, Wilentz RE, Hruban RH, Argani P. MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol. 2002 May;117(5):791-6. abstract
  116. Yeo CJ, Cameron JL, Lillemoe KD, Sohn TA, Campbell KA, Sauter PK, Coleman J, Abrams RA, Hruban RH. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg. 2002 Sep;236(3):355-66; discussion 366-8. abstract
  117. Tersmette AC, Petersen GM, Offerhaus GJ, Falatko FC, Brune KA, Goggins M, Rozenblum E, Wilentz RE, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer. Clin Cancer Res 7:738-44, 2001. (abstract) | (full text)
  118. Tobi M, Hatfield J, Adsay V, Galagan K, Kozarek R, Inagaki M, Kasai S, Tokusashi Y, Obara T, Hruban RH, Lough J, Barkun AN, Jabbari M, Sheikh R, Ruebner B, Lawson MJ, Ben-Josef E, Fligiel S. Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms. Int J Pancreatol. 2001;29(3):141-50. abstract
  119. Ueki T, Toyota M, Skinner H, Walter KM, Yeo CJ, Issa JP, Hruban RH, Goggins M. Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. Cancer Res 61:8540-6, 2001. (abstract)
  120. Wilentz RE, Albores-Saavedra, Hruban RH. The exocrine pancreas. In Pathology of Incipient Neoplasia, 3rd Ed. Philadelphia: WB Saunders, Co., 2001.

  121. Abraham SC, Wu TT, Klimstra DS, Finn LS, Lee JH, Yeo CJ, Cameron JL, Hruban RH. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/beta-catenin pathway and chromosome 11p. Am J Pathol 159:1619-1627, 2001. abstract
  122. Argani P, Iacobuzio-Donahue C, Ryu B, Rosty C, Goggins M, Wilentz RE, Murugesan SR, Leach SD, Jaffee E, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 7:3862-8, 2001. (abstract)
  123. Argani P, Rosty C, Reiter RE, Wilentz RE, Murugesan SR, Leach SD, Ryu B, Skinner HG, Goggins M, Jaffee EM, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma. Cancer Res 61:4320-4324, 2001. (abstract) | (full text)
  124. Hruban RH. Pancreatic cancer: from genes to patient care. J Gastrointest Surg. 2001 Nov-Dec;5(6):583-7. Review.
  125. Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, Kern SE, Klimstra DS, Kloppel G, Longnecker DS, Luttges J, Offerhaus GJ. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001 May;25(5):579-86. abstract
  126. Hruban RH, Canto MI, Yeo CJ. Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer. Dig Dis. 2001;19(1):76-84. abstract
  127. Jaffee EM, Hruban RH, Biedrzycki B, Laheru D, Schepers K, Sauter PR, Goemann M, Coleman J, Grochow L, Donehower RC, Lillemoe KD, O'Reilly S, Abrams RA, Pardoll DM, Cameron JL, Yeo CJ. Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase i trial of safety and immune activation. J Clin Oncol 19:145-56, 2001. abstract
  128. Jones JB, Song JJ, Hempen PM, Parmigiani G, Hruban RH, Kern SE. Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res 2001 Feb 15;61(4):1299-304. abstract
  129. Kern S, Hruban R, Hollingsworth MA, Brand R, Adrian TE, Jaffee E, Tempero MA. A white paper: the product of a pancreas cancer think tank. Cancer Res. 2001 Jun 15;61(12):4923-32. abstract
  130. McCarthy DM, Brat DJ, Wilentz RE, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling. Hum Pathol. 2001 Jun;32(6):638-42. abstract
  131. Ryu B, Jones J, Hollingsworth MA, Hruban RH, Kern SE. Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res 61: 1833-1838, 2001. abstract
  132. Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 159:2017-22, 2001. abstract
  133. Smith AE, Levi AW, Nadasdy T, Campbell KA, Fishman EK, Hruban RH. The pigmented "black" neuroendocrine tumor of the pancreas: a question of origin. Cancer. 2001 Oct 1;92(7):1984-91. abstract
  134. Sohn TA, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Lillemoe KD. Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity. Ann Surg. 2001 Sep;234(3):313-21. abstract
  135. Su GH, Bansal R, Murphy KM, Montgomery E, Yeo CJ, Hruban RH, Kern SE. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci USA 98:3254-7, 2001. abstract
  136. Tascilar M, Offerhaus GJ, Altink R, Argani P, Sohn TA, Yeo CJ, Cameron JL, Goggins M, Hruban RH, Wilentz RE. Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct. Am J Clin Pathol 116:831-7, 2001. (abstract)
  137. Hilgers W, Koerkamp BG, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE. Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. Genes Chromosomes Cancer. 2000 Mar;27(3):239-43. abstract
  138. Hilgers W, Song JJ, Haye M, Hruban RR, Kern SE, Fearon ER. Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers. Genes Chromosomes Cancer. 2000 Apr;27(4):353-7. abstract
  139. Huang JJ, Yeo CJ, Sohn TA, Lillemoe KD, Sauter PK, Coleman J, Hruban RH, Cameron JL. Quality of life and outcomes after pancreaticoduodenectomy. Ann Surg. 2000 Jun;231(6):890-8. abstract
  140. Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Argani P, Sohn TA, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000 Sep;157(3):755-61. abstract
  141. Iacobuzio-Donahue CA, Wilentz RE, Argani P, Yeo CJ, Cameron JL, Kern SE, Hruban RH. Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression. Am J Surg Pathol. 2000 Nov;24(11):1544-8. abstract
  142. Sohn TA, Campbell KA, Pitt HA, Sauter PK, Coleman JA, Lillemo KD, Yeo CJ, Cameron JL. Quality of life and long-term survival after surgery for chronic pancreatitis. J Gastrointest Surg 4:355-365, 2000. abstract
  143. Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, Sauter PK, Coleman J, Hruban RH, Lillemoe KD. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2000 Nov-Dec;4(6):567-79. abstract
  144. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science 289:1121-2,2000. abstract
  145. Ueki T, Toyota M, Sohn TA, Yeo CJ, Issa J-PJ, Hruban RH, Goggins M. Hypermethylation of multiple genes in pancreatic carcinoma. Cancer Res, 60: 1835-1839, 2000. abstract
  146. van den Berg W, Tascilar M, Offerhaus GJ, Albores-Saavedra J, Wenig BM, Hruban RH, Gabrielson E. Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. Mod Pathol. 2000 Jan;13(1):86-91. abstract
  147. Wilentz RE, Albores-Saavedra J, Hruban RH. Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol. 2000 Feb;17(1):31-42.
  148. Wilentz RE, Goggins M, Redston M, Marcus VA, Adsay NV, Sohn TA, Kadkol SS, Yeo CJ, Choti M, Zahurak M, Johnson K, Tascilar M, Offerhaus GJ, Hruban RH, Kern SE. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: A newly described and characterized entity. Am J Pathol 156:1641-1651,2000. abstract
  149. Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, Yeo CJ, Kern SE, Hruban RH. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 60:2002-2006, 2000. abstract
  150. Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, Sohn TA, Yeo CJ, Kern SE, Hruban RH. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation. Am J Pathol 156:37-43, 2000. abstract
  151. Dai JL, Bansal RK, Kern SE. G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation. Proc Natl Acad Sci, USA 96: 1427-1432, 1999.
  152. Hilgers W, Tang DJ, Sugar AY, Shekher MC, Hruban RH, Kern SE. High-resolution deletion mapping of chromosome arm 1p in pancreatic cancer identifies a major consensus region at 1p35. Genes Chromosomes and Cancer 24:351-355,1999. abstract
  153. Hruban RH, Offerhaus GJA, Graves T, Parnes H, Albores-Saavedra. Molecular pathology of early pancreatic cancer. In S. Scrivastava, DE Henson and A Gazdar, eds. Molecular Pathology of Early Cancer. IOS Press, Chapter 19, pages 289-299, 1999.
  154. Hruban RH, Yeo CJ, Kern SE. Screening for pancreatic cancer. In Screening Theory and Practice, B. Kramer, P. Provok and Y. Gohagan, eds. Dekker Pub., Chapter 17, 441-459, 1999.
  155. Lillemoe KD, Kaushal S, Cameron JL, Sohn TA, Pitt HA, Yeo CJ. Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg 1999 May;229(5):693-8; discussion 698-700. abstract
  156. Sohn TA, Lillemoe KD, Cameron JL, Pitt HA, Huang JJ, Hruban RH, Yeo CJ. Reexploration for periampullary carcinoma. Ann of Surg 229(3):393-400, 1999. abstract
  157. Sturm PDJ, Rauws EAJ, Hruban RH, Caspers E, Ramsoekh TB, Huibregtse K, Noorduyn LA, Offerhaus JA. Clinical value of k-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malingant extrahepatic bile duct stenosis. Clinical Cancer Research 5:629-635, 1999. abstract
  158. Su GH, Hruban RH, Bansal RK, Bova GS, Tang DT, Shekher MC, Westerman AM, Entius MM, Goggins M, Yeo CJ, Kern SE. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol 154:1835-40, 1999. abstract
  159. Wilentz RE, Albores-Saavedra J, Zahurak M, Talamini MA, Yeo CJ, Cameron JL, Hruban RH. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 23:1320-7, 1999. abstract
  160. Yeo CJ. Tumor suppressor genes: a short review. Surgery 125:363-6, 1999. abstract
  161. Yeo CJ. The Whipple procedure in the 1990s. Adv Surg 32:271-303, 1999. abstract
  162. Yeo CJ, Cameron JL. Pancreatic cancer. Curr Probl Surg 36:59-152, 1999. abstract
  163. Yeo CJ, Cameron JL, Sohn TA, Coleman J, Sauter PK, Hruban RH, Pitt HA, Lillemoe KD. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg 1999 May;229(5):613-22. abstract
  164. Bakotic BW, Robinson MJ, Sturm PDJ, Hruban RH, Offerhaus GJA, Albores-Saavedra J. Pyloric gland adenoma of the main pancreatic duct. Am J Surg Pathol 23(2):227-231, 1999. abstract
  165. Dai JL, Turnacioglu KK, Schutte M, Sugar AY, Kern SE. Dpc4 transcriptional activation and dysfunction in cancer cells. Cancer Research 58: 4592-4597, 1998.
  166. Goggins M, Lietman A, Miller RE, Yeo CJ, Jaffee E, Coleman J, O'Reilly S, Cullen B, Cameron JL, Kern SE, Hruban RH. Use and benefits of a Web site for pancreatic cancer (letter). JAMA. 280: 1309-1310, 1998. full article
  167. Goggins M, Offerhaus GJA, Hilgers W, Griffin CA, Shekher M, Tang D, Sohn TA, Yeo CJ, Kern SE and Hruban RH. Adenocarcinoma of the pancreas with DNA replication errors (RER+) are associated with a charcteristic histopathology: poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152:1501-7, 1998. abstract
  168. Goggins M, Shekher M, Kenan T, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor ß receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 58:5329-5332, 1998. abstract
  169. Hruban RH, Offerhaus GJA. Molecular diagnosis of cancer and micrometastases. Adv Anat Pathol 5: 175-178, 1998.
  170. Hruban RH, Offerhaus GJA, Kern SE, Goggins M, Wilentz RE, Yeo CJ. Tumor suppressor genes in pancreatic cancer. J Hepatobiliary and Pancreatic Surg 5:383-391, 1998.
  171. Hruban RH, Petersen GM, Ha P, Kern SE. Genetics of pancreatic cancer: From genes to families. Surg. Onc. Clin N Amer 7:1-23, 1998. abstract
  172. Jaffee EM, Abrams R, Cameron JL, Donehower R, Duerr M, Gossett J, Greten TF, Growchow L, Hruban RH, Kern S, Lillemoe KD, OReilly S, Pardoll D, Pitt HA, Sauter P, Weber C, Yeo CJ. A phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with GM-CSF gene for the treatment of pancreatic adenocarcinoma. Human Gene Therapy 9:1951-1971, 1998.
  173. Jaffee EM, Schutte M, Gossett J, Morsberger LA, Adler AJ, Thomas M, Greten TF, Hruban RH, Yeo CJ, Griffin CA. Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. Cancer J Sci Am 4:194-203, 1998. abstract
  174. Kern SE. Advances from genetic clues in pancreatic cancer. Curr Opin Onc 1998; 10:74-80. abstract
  175. Moskaluk CA, Hruban RH, Lietman A, Smyrk T, Fusaro L, Lynch J, Yeo CJ, Jackson CE, Lynch HT, Kern SE. Novel germline p16INK4A (Asp145Cys) in a family with multiple pancreatic carcinomas. Human Mutation, Mutation in Brief #148, 12:70-73, 1998.
  176. Moskaluk CA, Kern SE. Molecular genetics of pancreatic cancer. (Chapter) In Advances in Pancreatic Cancer, H Reber, ed., The Humana Press, 1998.
  177. Okami K, Wu L, Riggins G, Cairns P, Goggins M, Evron E, Halachmi N, Ahrendt SA, Reed AL, Hilgers W, Kern SE, Sidransky D, Jen J. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res 58:509-11, 1998. abstract
  178. Phan GQ, Yeo CJ, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL. Surgical experience with pancreatic and peripancreatic neuroendocrine tumors: Review of 125 patients. J Gastrointest Surg 2: 472-482, 1998. abstract
  179. Sirard C, de la Pompa JL, Elia AJ, Itie A, Mirtsos C, cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW. The tumor suppressor gene Dpc4/Smad4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12:107-19, 1998. abstract
  180. Slebos RJC, Ceha HM, Kern SE, Hruban RH. Molecular Genetics of Pancreas Cancer. In Current Topics in Pancreas Cancer, Dougan M, Sarkar F, eds. BioTechniques Books Publishers, MA, Chapter 5, pages 65-82, 1998.
  181. Sohn TA, Lillemoe KD, Cameron JL, Pitt HAS, Kaufman HS, Hruban RH, Yeo CJ. Adenocarcinoma of the duodenum: factors influencing long-term survival. J Gastrointest Surg 2:79-87, 1998.
  182. Sohn TA, Yeo CJ, Cameron JL, Lillemoe KD, Talamini MA, Hruban RH, Sauter PK, Coleman J, Ord SE, Grochow LB, Abrams RA and Pitt HA. Should pancreaticoduodenectomy be performed in octogenarians? J Gastrointest Surg 2:207-216, 1998.
  183. Sosa JA, Bowman HM, Gordon TA, Bass EB, Yeo CJ, Lillemoe KD, Pitt HA, Tielsch JM, Cameron JL. Importance of hospital volume in the overall management of pancreatic cancer. Ann Surg 1998 Sep;228(3):429-388. abstract
  184. Sturm PD, Baas IO, Clement MJ, Nakeeb A, Offerhaus JGA, Hruban RH, Pitt HA. Alterations of the p53 tumor-suppressor gene in K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area. Int J Cancer 78(6):695-8, 1998. abstract
  185. Sturm PDJ, Hruban RH, Ramsoekh TB, Noorduyn LA, Tytgat GNJ, Gouma DJ, Offerhaus GJA. The potential diagnostic use of k-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region. J Pathol 186:247-253, 1998. abstract
  186. Su GH, Hilgers W, Shekher M, Tang D, Yeo CJ, Hruban RH, Kern SE. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor- suppressor gene. Cancer Res 58:2339-42, 1998. abstract
  187. Talamini MA, Moesinger R, Yeo CJ, Poulose B, Hruban RH, Cameron JL, Pitt HA. Cystadenomas of the pancreas: is enucleation an adequate operation? Ann Surg 227(6):896-903, 1998. abstract
  188. Westra WH, Sturm P, Drillenburg P, Choti MA, Klimstra DS, Albores-Saavedra J, Montag A, Offerhaus GJA, Hruban RH. K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: Genetic evidence to support origin from the duct epithelium. Am J Surg Pathol 22:1247-54, 1998. abstract
  189. Wilentz RE, Chung CH, Sturm PDJ, Musler A, Sohn TA, Offerhaus GJA, Yeo CJ, Hruban RH and Slebos RJC. K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma. Cancer 82:96-103, 1998. abstract
  190. Wilentz RE, Geradts J, Maynard R, Offerhaus GJA, Kang M, Goggins M, Yeo CJ, Kern E, Hruban RH. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Research 58:4740-4744, 1998. abstract
  191. Wilentz R, Hruban RH. Pathology of cancer of the pancreas. In Pitt HA, ed. W.B. Saunders Pub, Phila PA. Surgical Oncology Clinics of North America 7:43-65, 1998 (Chapter).
  192. Wilentz R, Slebos RJC, Hruban RH. Screening for pancreatic cancer using techniques to detect altered gene products. In H. Reber, ed. Advances in Pancreatic Cancer Humana Press, Chapter 6, 113-136, 1998.
  193. Yeo CJ. Leak after Whipple resection: preventable? HPB Surg 11:133-6, 1998. abstract
  194. Yeo CJ. Pancreatic cancer: 1998 update. J Am Coll Surg 187:429-42, 1998. abstract
  195. Yeo CJ. Pylorus-preserving pancreaticoduodenectomy. Surg Oncol Clin N Am 7:143-56, 1998. abstract
  196. Yeo CJ, Cameron JL. Prognostic factors in ductal pancreatic cancer. Langenbecks Arch Surg 383:129-33, 1998. abstract
  197. Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Lillemoe KD, Pitt HA. Periampullary adenocarcinoma: analysis of 5-year survivors. Ann Surg 227:821 - 831, 1998. abstract
  198. Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler K, Vogelstein B, Kern SE. Human Smad3 and Smad4 are sequence-specific transcription activators. Molecular Cell, 1: 611-617, 1998.
  199. Brat DJ, Lillimoe KD, Yeo CJ, Warfield PB, Hruban RH. Progression of pancreatic intraductal lesions (High grade PanIN) to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol 22:163-169, 1998. abstract
  200. Zhou W, Sokoll LJ, Bruzek DJ, Zhang L, Velculescu VE, Goldin SB, Hruban RH, Kern SE, Hamilton SR, Chan DW, Vogelstein B, Kinzler KW. Identifying markers for pancreatic cancer by gene expression analysis. Cancer Epidemiol Biomarkers Prev 7:109-12, 1998. abstract
  201. Allison DC, Piantadosi S, Hruban RH, Dooley WC, Fishman E, Lin P, Cameron JL. DNA content and other factors associated with ten year survival, after resection, of pancreatic carcinoma. Journal of Surgical Oncology 67:151-159, 1998. abstract
  202. Chakravarthy, A. and Abrams, R.A.: Radiation Therapy and 5-Fluorouracil in Pancreatic Cancer. Seminars in Rad. Onc. 7:4, 1-9, 1997.
  203. Coleman J. Esophageal, stomach, liver, gallbladder, and pancreatic cancers. In SL Groenwald, MH Frogge, M Goodman, CH Yarbro, eds. Cancer Nursing Principles and Practice. Sudbury, MA: Jones and Bartlett Publishers, pp. 1082-1144, 1997.
  204. Fujii H, Inagaki M, Kasai, Miyokawa N, Toshihiko Y, Gabrielson E, Hruban RH. Genetic progression and heterogeneity in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathl 151(5):1447-1454, 1997. abstract
  205. Goggins M, Hruban RH, Kern SE. Hereditary Pancreatic Cancer - Part I: Genetic profile of the disease. Oncology News International 1997. Hereditary pancreatic Cancer - Part II: The candidate genes. Oncology New International 1997. Hereditary Pancreatic Cancer - Part III: Clinical recognition of hereditary predisposition. Oncology News International 1997.
  206. Hahn SA, Kern SE, Schmiegel W-H. Neue molekularbiologische Erkenntnisse aus des Pankreaskarzinom-Forschung, Diagnostische und therapeutische Perspektiven. Deutsches Drzteblatt 1997; 94:3-10.
  207. Hruban RH, Sturm PDJ, Slebos RJC, Wilentz RE, Musler AR, Yeo CJ, Sohn TA, van Velthuysen MLF and Offerhaus GJA. Can k-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients. Am J Pathol 151:943-949, 1997. abstract
  208. Hruban RH, Yeo CJ, Kern SE. Pancreatic Cancer. In Genetic Basis of Human Cancer, Vogelstein B, Kinzler KW, eds. McGraw Hill Publishers, NJ. Chapter 33, pages 603-613,1997.
  209. Hruban RH, Yeo CJ, Kern SE. Pancreatic Cancer. In Molecular and Mendelian Basis of Inherited Disease. Scriver, Beaudet, Sly and Valle, eds. McGraw Hill, Inc., 7th Ed., Vol 1 Chapter 177:CD ROM (1997).
  210. Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997; 57:2140-2143. abstract
  211. Moskaluk C, Hruban RH, Schutte M, Lietman AS, Smyrk T, Fusaro L, Rusar R, Lynch J, Yeo CJ, Jackson CE, Lynch HT, Kern SE. Genetic sequencing of DPC4 in the analysis of familial pancreatic cancer. Diag Mol Pathol 6:85-90, 1997. abstract
  212. Moskaluk C, Kern SE. Microdissection and PCR amplification of genomic DNA from histologic tissue sections. Am J Pathol 1997; 150:1547-1552. abstract
  213. Phan GQ, Yeo CJ, Cameron JL, Maher M, Hruban RH and Udelsman R. Pancreaticoduodenectomy for selected periampullary neuroendocrine tumors: Fifty patients. Surgery 122:989-997, 1997. abstract
  214. Rozenblum E, Schutte M, Goggins M, Hahn SA, Lu J, Panzer S, Zahurak M, Goodman SN, Hruban RH, Yeo CJ, Kern SE. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997; 57:1731-1734. abstract
  215. Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, Baylin SB, Kern SE, Herman JG. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997; 57:3126-3130. abstract
  216. Sosa JA, Bowman HM, Bass EB, Yeo CJ, Lillemoe KD, Pitt HA, Gordon TA and Cameron JL. Importance of hospital volume in the surgical management of pancreatic cancer. Surg Forum 48:584-586, 1997.
  217. Talamini MA, Moesinger RC, Pitt HA, Sohn TA, Hruban RH, Lillemoe KD, Yeo CJ, and Cameron JL. Adenocarcinoma of the ampulla of Vater: A 28-year experience. Ann Surg 225:590-600, 1997. abstract
  218. Thuluvath PJ, Rai R, Venbrux AC and Yeo CJ. Cholangiocarcinoma: A review. Gastroenterologist 5:306-315, 1997. abstract
  219. Yeo, CJ, Abrams, R.A., Grochow, L.B., Sohn, T.A., Ord, S.E., Hruban, R.H., Zahurak, M.L., Coleman, J.A., Sauter, P.K., Pitt, H.A., Lillemoe, K.D., and Cameron, J.L.: Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: Postoperative Adjuvant Chemoradiation Improves Survival: A Prospective, Single Institution Experience. Annals of Surgery, 225:621-636, 1997. abstract
  220. Yeo CJ, Cameron JL. The pancreas. In Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 15th edition, ed. Sabiston DC Jr; W.B. Saunders Co, Philadelphia, p 1152-1186, 1997.
  221. Yeo, CJ, Cameron, JL, Sohn, TA, Lillemoe, KD, Pitt, HA, Talamini, MA, Hruban, RH, Ord, SE, Sauter, PK, Coleman, JA, Zahurak, ML, Grochow, LB, and Abrams, RA: Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s, Pathology, Complications, and Outcomes. Annals of Surgery, 226, 3:248-260, 1997. abstract
  222. Yeo CJ, Kern SE, Hruban RH, Cameron JL. Pancreatic cancer: new aspects of genetics and surgical management. The Johns Hopkins experience. Asian J Surg 1997; 20:221-228.
  223. Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B, Kinzler KW. Gene expression profiles in normal and cancer cells. Science 1997; 276:1268-1272. abstract
  224. Brat CJ, Hahn SA, Griffin CA, Yeo CJ, Kern SE, Hruban RH. The structural basis of molecular genetic deletions: An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma. Am J Pathol 1997; 150:383-391. abstract
  225. Bluemke DA, Abrams RA, Yeo CJ, Cameron JL and Fishman EK. Recurrent pancreatic adenocarcinoma: Spiral CT evaluation following the Whipple procedure. RadioGraphics 17:303-313, 1997. abstract
  226. Carducci MA, Abrams RA, Yeo CJ, Hruban RH, Zahurak ML, Cameron JL, Grochow LB. Early evaluation of abdominal/hepatic irradiation and 5-FU/leucovorin infusion after pancreaticoduodenectomy. Int J Rad Onc Biol Phys 35:143-150, 1996. abstract
  227. Coleman J. Supportive Management of the Patient with Pancreatic Cancer: Role of the Oncology Nurse. Oncology 10(9):23-25, 1996.
  228. Day JD, DiGiuseppe JA, Yeo CJ, Lai-Goldman M, Anderson SM, Goodman SN, Kern SE, Hruban RH. Immunohistochemical evaluation of HER-2neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Hum Pathol 27: 119-124, 1996. abstract
  229. DiGiuseppe JA, Yeo CJ, Hruban RH. Molecular biology and the diagnosis and treatment of adenocarcinoma of the pancreas. Adv Anat Pathol 3:139-155, 1996.
  230. Goggins M, Schutte M, Lu J, Moskaluk CA, Weinstein CL, Petersen GM, Yeo CJ, Jackson CE, Lynch HT, Hruban RH and Kern SE. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996 56:5360-5364. abstract
  231. Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, daCosta LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. DPC4, a candidate tumor-suppressor gene at human chromosome 18q21.1. Science 271:350-353, 1996. abstract
  232. Hahn SA, Hoque ATMS, Moskaluk CA, daCosta LT, Schutte M, Rozenblum E, Seymour AB, Weinstein CL, Yeo CJ, Hruban RH, Kern SE. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res 56:490-494, 1996. abstract
  233. Kern SE. Oncogenes/proto-oncogenes and tumor suppressor genes in human neoplasia. In Cellular and Molecular Pathogenesis. Sirica AE, ed. Raven Press 1996. pp 321-340.
  234. Lillemoe KD, Cameron JL, Yeo CJ, Sohn TA, Nakeeb A, Sauter PK, Hruban RH, Abrams RA, Pitt HA. Pancreaticoduodenectomy: does it have a role in the palliation of pancreatic cancer? Ann Surg 223:718-728, 1996. abstract
  235. Lynch HT, Smyrk T, Kern SE, Hruban RH, Lightdale CJ, Lemon SJ, Lynch JF, Fusaro LR, Fusaro RM, Ghadirian P. Familial pancreatic cancer: A review. Seminars in Oncology 1996; 23:251-275.
  236. Maher MM, Yeo CJ, Lillemoe KD, Roberts JR, Cameron JL. Pancreas-sparing duodenectomy for infra-ampullary duodenal pathology. Am J Surg 171:62-67, 1996. abstract

  237. Moskaluk CA, Kern SE. Mad About Cancer: DPC4 and Other TGF-ß Pathway Genes in Human Cancer (Review) BBA Reviews Online 1996; 1288: M31-M33.
  238. Nakeeb, A, Pitt, HA, Taylor, AS, Coleman, JA, Abrams, RA, and Piantadosi, S: Cholangiocarcinoma: A Spectrum Of Intrahepatic Perihilar And Distal Tumors. Annals of Surgery, 224:4, 463-475, 1996.
  239. Pitt, HA, Abrams, RA, and Grochow, LB. Cancer of the Biliary Tree. In: V DeVita, S Hellman, and S Rosenberg, eds. Cancer: Principles and Practice of Oncology. 5th edition. Chapter 32.4, pp. 1114, 1996.
  240. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Wilson JKV, Markowitz SD, Kinzler KW, Vogelstein B. MAD-related genes in the human. Nature Genetics 1996; 13:347-349. abstract
  241. Rozenblum E, Schutte M, Kern SE. INK4 genes in pancreatic carcinoma. Oncology Reports 1996; 3:743-745.
  242. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA Jr, Meltzer PS, Hahn SA, Kern SE. DPC4 gene in various tumor types. Cancer Res 56:2527-2530, 1996. abstract
  243. Schutte M, Kern SE. The molecular genetics of pancreatic adenocarcinoma. In Pancreatic Cancer: Molecular and Clinical Advances. Neoptolemos and N. Lemoine, eds., Oxford: Blackwell Scientific, 1996, pp.115-132.
  244. Yeo CJ. Pancreatic cancer. Coping 10:39-41, 1996.
  245. Yeo CJ, Cameron JL. The alternative techniques for performing the Whipple operation. Adv Surg 30:293-310, 1996.
  246. Yeo CJ, Cameron JL. Pancreatic nodal metastases: biologic significance and therapeutic considerations. Surg Onc Clin N Am 5:145-157, 1996.
  247. Barnes SA, Lillemoe KD, Kaufman HS, Sauter PK, Yeo CJ, Talamini MA, Pitt HA, Cameron JL. Pancreaticoduodenectomy for benign disease. Am J Surg 171:131-135, 1996. abstract
  248. Abrams, R.A.: Role Of Radiation Therapy In The Management Of The Patient With Pancreatic Cancer. Oncology (Supplement), 10 (9):13-17, 1996.
  249. Cameron JL, Warshaw AL, Yeo CJ. Symposium: adenocarcinoma of the head, neck and uncinate process of the pancreas. Contemporary Surgery 48:355-368, 1996.
  250. Cameron JL. The current management of carcinoma of the head of the pancreas. Annu Rev Med 46:361-370, 1995. abstract
  251. Chakravarthy A, Abrams RA. Radiation therapy in the management of patients with malignant carcinoid tumors. Cancer 75:1386-90, 1995. abstract
  252. DiGiuseppe JA, Hruban RH. Pathobiology of cancer of the pancreas. Semin Surg Oncol 11:87-96, 1995 (Review article).
  253. DiGiuseppe JA, Redston MS, Yeo CJ, Kern SE, Hruban RH. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am J Pathol 147:884-888, 1995. abstract
  254. Gordon TA, Burleyson GP, Tielsch JM, Cameron JL. The effects of regionalization on cost and outcome for one general high-risk surgical procedure. Ann Surg 221:43-49, 1995. abstract
  255. Griffin CA, Hruban RH, Morsberger LA, Ellingham T, Long PP, Jaffee EM, Hauda KM, Boh-lander SK, Yeo CJ. Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 55:2394-2399, 1995. abstract
  256. Hahn SA, Kern SE. Molecular genetics of exocrine pancreatic neoplasms. (Chapter) Surg Clin N Amer 55:857-869, 1995. abstract
  257. Hahn SA, Kern SE, Schmiegel W-H. Molekularbiologische Verdnderungen bei gastrointestinalen Tumoren, Diagnostische und therapeutische Perspektiven. Deutsches Drzteblatt 1995; 92:137-143.
  258. Hahn SA, Seymour AB, Hoque ATMS, Schutte M, da Costa LT, Redston MS, Caldas C, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE. Allelotype of pancreatic adenocarcinoma using a xenograft model. Cancer Res 55:4670-4675, 1995. abstract
  259. Kuznetsov VA, Gusev YV, Senko OV, Ivshina AV, Dooley WC. Application of novel pattern recognition method to image cytometry and morphometry data to differentiate normal and tumor cells. Cell Vision, 1995.
  260. Lillemoe KD. Current management of pancreatic carcinoma. Ann Surg 221:133-148, 1995. abstract
  261. Lillemoe KD. Management of periampullary carcinoma. In: Cameron JL (ed). Current Surgical Therapy V. St. Louis, MO. Mosby-Year Book, Inc., pp 446-453, l995.
  262. Lumadue JA, Griffin CA, Osman M, Hruban RH. Familial pancreas cancer and the genetics of pancreas cancer. Surg Clin N Am 75:845-855, 1995. abstract
  263. Nakeeb A, Lillemoe KD, Cameron JL. The role of pancreaticoduodenectomy for locally recurrent or metastatic carcinoma to the periampullary region. J Am Coll Surg 180:188-192, 1995. abstract
  264. Nakeeb A, Pitt HA. Jaundice. In: Polk HC, Gardner B, Stone HH, eds. Basic Surgery, 5th edition. St. Louis: Quality Medical Publishing, Inc. 558-78, 1995.
  265. Pitt HA. Curative treatment for pancreatic neoplasms: Standard resection. In: Cameron JL, ed. Pancreatic Neoplasms. Surg Clin N Amer 75:891-904, 1995.
  266. Pitt HA, Dooley WC, Yeo CJ, Cameron JL. Malignancies of the biliary tree. Curr Probl Surg 32: 1-90, 1995.
  267. Pitt HA, Nakeeb A, Abrams RA, Coleman JA, Piantadosi S, Yeo CJ, Lillemoe KD, Cameron JL. Perihilar cholangiocarcinoma: postoperative radiotherapy does not improve survival. Ann Surg 221:787-798, 1995. abstract
  268. Schutte M, da Costa LT, Hahn SA, Moskaluk C, Hoque ATMS, Rozenblum E, Weinstein CL, Bittner M, Meltzer PS, Trent JM, Yeo CJ, Hruban RH, Kern SE. Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. Proc Natl Acad Sci USA 92:5950-5954, 1995. abstract
  269. Schutte M, daCosta L, Moskaluk C, Rozenblum E, Guan X, deJong PJ, Bittner M, Meltzer PS, Trent JM, Kern SE. Isolation of YAC insert sequences by representational difference analysis. Nucleic Acids Res 1995; 23:4127-4133. abstract
  270. Schutte M, Rozenblum E, Moskaluk CA, Guan X, Hoque ATMS, Hahn SA, da Costa LT, de Jong PJ, Kern SE. An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12-13. Cancer Res 1995 55:4570-4574. abstract
  271. Talamini MA, Fishman EK, Hruban RH, Pitt HA. Cystic neoplasms. In: HA Pitt, DL Carr-Locke, JT Ferrucci, eds. Hepatobiliary and Pancreatic Disease. The Team Approach to Management. Boston: Little, Brown & Company, 1995. (Chapter, 451-461).
  272. Tamm EP, Jones B, Yeo CJ, Maher MM, Cameron JL. Pancreaticogastrostomy and the Whipple procedure: radiographic appearance and complications. Radiology 196:251-255, 1995. abstract
  273. Yeo CJ. Bile duct cancer. In Cameron JL, ed. Current Surgical Therapy, 5th edition. St. Louis: Mosby-Year Book Inc., pp. 380-386, 1995.
  274. Yeo CJ. Management of complications following pancreaticoduodenectomy. Surg Clin N Am 75:913-924, 1995. abstract
  275. Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Goodman SN, Dooley WC, Coleman J, Pitt HA. Pancreaticoduodenectomy for cancer of the head of the pancreas: 201 patients. Ann Surg 221:721-733, 1995. abstract
  276. Yeo CJ, Cameron JL, Maher MM, Sauter PK, Zahurak ML, Talamini MA, Lillemoe KD, Pitt HA. A prospective randomized trial of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy. Ann Surg 222:580-592, 1995. abstract
  277. Bluemke DA, Cameron JL, Hruban RH, Pitt HA, Siegelman SS, Soyer P, Fishman EK. Potentially resectable pancreatic adenocarcinoma: spiral CT assessment with surgical and pathologic correlation. Radiology 197:381-5, 1995. abstract
  278. Abrams, R.A., and Grochow, L.B. Adjuvant Therapy With Chemotherapy and Radiation Therapy in the Management of Carcinoma of the Pancreatic Head. In: The Surgical Clinics of North America. eds. Dr. Cameron. W. B. Saunders Company, Philadelphia, PA., 75(5), pp. 925-938, 1995.
  279. Caldas C, Kern SE. K-ras mutation and pancreatic carcinoma. (Review) Int J Pancreatol 16:192, 1995.
  280. Lillemoe KD. Pancreatic disease in the elderly. Surg Clin N Am 74:317-344, l994. abstract
  281. Danner DB, Hruban RH, Pitt HA, Hayashi R, Griffin CA, Perlman EJ. Primitive neuroectodermal tumor arising in the pancreas. Mod Pathol 7:200-204, 1994. abstract
  282. DiGiuseppe JA, Hruban RH, Goodman SN, Polak M, van den Berg FM, Allison DC, Cameron JL, Offerhaus GJA. Overexpression of p53 protein in adenocarcinoma of the pancreas. Am J Clin Pathol 101:684-688, 1994. abstract
  283. DiGiuseppe JA, Hruban RH, Offerhaus GJA, Clement MJ, van den Berg FM, Cameron JL, van Mansfeld ADM. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma. Am J Pathol 144:889-895, 1994. abstract
  284. Griffin CA, Hruban RH, Long PP, Morsberger LA, Douna-Issa F, Yeo CJ. Chromosome abnormalities in pancreatic adenocarcinoma. Genes Chromosom Cancer 9:93-100, 1994. abstract
  285. Huang A, Golumbek P, Amazadeh M, Jaffee EM, Pardoll DM, Levitsky H. The role of bone marrow derived cells in presenting MHC class I rstricted tumor antigens. Science 64:961-965, 1994. abstract
  286. Jaffee EM, Pardoll DM. Gene therapy: Its potential application the treatment of renal cell carcinoma. Sem Oncol 22 (1):81-91, 1994.
  287. Kern SE. p53: Tumor suppression through control of the cell cycle. (Editorial) Gastroenterology 1994; 106:1708-1711.
  288. Long PP, Hruban RH, Lo R, Yeo CJ, Morsberger LA, Griffin CA. Chromosome analysis of nine endocrine neoplasms of the pancreas. Cancer Genet Cytogenet 77:55-59, 1994. abstract
  289. Pitt HA. Classification, diagnosis, staging and preoperative preparation of pancreatic and periampullary neoplasms. Braasch JW, Tompkins RK, eds. Surgical Disease of the Biliary Tract and Pancreas. Philadelphia, Mosby-Year Book, 514-527, 1994.
  290. Redston MS, Caldas C, Seymour AB, Hruban RH, da Costa L, Yeo CJ, Kern SE. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 54:3025-3033, 1994. abstract
  291. Savader BL, Fishman EK, Savader SJ, Cameron JL. CT arterial portography vs pancreatic arteriography in the assessment of vascular involvement in pancreatic and periampullary tumors. J Comput Assist Tomogr 18(6):916-920, 1994. abstract
  292. Seymour AB, Hruban RH, Redston M, Caldas C, Powell SM, Kinzler KW, Yeo CJ, Kern SE. Allelotype of pancreatic adenocarcinoma. Cancer Res 54:2761-2764, 1994. abstract
  293. Tulinius H, Olafsdottir GH, Sigvaldason H, Tryggvadottir L, Bjarnadottir K. Neoplastic diseases in families of breast cancer patients. J Med Genet 31:618-621, 1994. abstract
  294. Yeo CJ, Cameron JL. Arguments against radical (extended) resection for adenocarcinoma of the pancreas. Adv Surg 27:273-284, 1994.
  295. Yeo CJ, Hruban RH, Kern SE, Abrams RA, Grochow LB, Griffin CA, Cameron JL. Adenocarcinoma of the pancreas: factors influencing outcome after pancreaticoduodenectomy - The Johns Hopkins experience. (Review) Cancer Bulletin 46:504-510, 1994.
  296. Yeo CJ, Pitt HA, Cameron JL. Bile duct carcinoma: diagnosis. In Terblonche J, ed. Hepatobiliary Malignancy: Its Multidisciplinary Management. Kent: Hodder and Stoughton, pp. 395-401, 1994.
  297. Yeo CJ, Pitt HA, Cameron JL. Bile duct carcinoma: outcome, prognosis and follow-up. In In Terblonche J, ed. Hepatobiliary Malignancy: Its Multidisciplinary Management. Kent: Hodder and Stoughton, pp. 479-484, 1994.
  298. Caldas C, Hahn SA, Hruban RH, Redston MS, Yeo CJ, Kern SE. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 54:3568-3573, 1994. abstract
  299. Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8:27-32,1994. abstract
  300. Byrd DR, Hoffman JP, Yeo CJ, Fernandez-del Castillo C, Foo ML, Evans DB. Current clinical trials and investigational programs for patients with resectable and advanced pancreatic cancer. Can Bul 46:532-537, 1994.
  301. Ahrendt SA, Pitt HA. Pancreatic and peripancreatic neoplasia. In: Bayless TS, ed. Current Therapy in Gastroenterology and Liver Disease. Philadelphia, Mosby-Year Book, 660-63, 1994.
  302. Cameron JL. Rapid exposure of the portal and superior mesenteric veins. "Surgeon at Work". Surg Gynecol Obstet 176:395-398, 1993.
  303. Lillemoe KD, Cameron JL, Kaufman HS, Yeo CJ, Pitt HA, Sauter PK. Chemical splanchnicectomy in patients with unresectable pancreatic cancer: a prospective randomized trial. Ann Surg 217:447-457, l993. abstract
  304. Lillemoe KD, Sauter PK, Pitt HA, Yeo CJ, Cameron JL. Current status of surgical palliation of periampullary carcinoma. Surg Gynecol Obstet 176:1-10, l993. abstract
  305. Cameron JL, Pitt HA, Yeo CJ, Lillemoe KD, Kaufman HS, Coleman J. One hundred and forty-five consecutive pancreaticoduodenectomies without mortality. Ann Surg 217:430-438, 1993. abstract
  306. Dooley WC, Gusev Y. Simulation model of chromosome dynamics in proliferating tumor cell populations. Cell Prolif 26:372, 1993.
  307. Dooley WC, Gusev Y, Tindler A, He M. Value of touch preps for clinical cytometry of scirrhus tumors. Cell Prolif 26:397, 1993.
  308. Dranoff G, Jaffee EM, Lazenby A, Golumbek P, Levitsky H, Brass AK, Jackson V, Hamada H, Pardoll DM, Mulligan RC. Vaccination with irradiated tumor cells engineered to secrete murine GM-CSF stimulates potent specific and long lasting anti-tumor immunity. Proc Natl Acad Sci USA 90:3539-3543, 1993. abstract
  309. Gold EB, Cameron JL. Chronic pancreatitis and pancreatic cancer. N Engl J Med 328:1485-1486, 1993.
  310. Hruban RH, van Mansfeld ADM, Offerhaus GJA, van Weering HJ, Allison DA, Goodman SN, Kensler TW, Bose KK, Cameron JL, Bos JL. K-ras oncogene activation in adenocarcinoma of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele specific oligonucleotide hybridization. Am J Pathol 143:545-554, 1993. abstract
  311. Jaffee EM, Dranoff G, Cohen LK, Hauda KM, Clift S, Marshall FF, Mulligan RC, Pardoll DM. High efficiency gene transfer into primary human tumor explants without cell selection. Cancer Res 53:2221-2226, 1993. abstract
  312. Kern SE. Clonality: More than just a tumor-progression model. (Editorial) J Natl Can Inst 1993; 85:1020-1021.
  313. Udelsman R, Yeo CJ, Hruban RH, Pitt HA, Niederhuber JE, Coleman J, Cameron JL. Pancreaticoduodenectomy for selected pancreatic endocrine tumors. Surg Gynecol Obstet 177: 269-278, 1993. abstract
  314. Yeo CJ, Barry MK, Sauter PK, Sostre S, Lillemoe KD, Pitt HA, Cameron JL. Erythromycin accelerates gastric emptying following pancreaticoduodenectomy: a prospective, randomized, placebo-controlled trial. Ann Surg 218:229-238, l993. abstract
  315. Yeo CJ, Wang BH, Anthone GJ, Cameron JL. Surgical experience with pancreatic islet-cell tumors. Arch Surg 128:1143-1148, 1993. abstract
  316. Bose KK, Allison DC, Hruban RH, Piantadosi S, Zahurak M, Dooley WC, Lin P, Cameron JL. A comparison of flow cytometric and absorption cytometric DNA values as prognostic indicators for pancreatic carcinoma. Cancer 71:691-700, 1993. abstract
  317. Yung BC-K, Sostre S, Yeo CJ, Pitt HA, Cameron JL. Comparison of left anterior oblique, anterior, and geometric mean methods in gastric emptying assessment of postpancreatico-duodenectomy patients. Clin Nucl Med 18:776-781, 1993. abstract
  318. Crist DW, Cameron JL. The current status of the Whipple operation for periampullary carcinoma. Adv Surg 25:21-49, 1992.
  319. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256:827-830, 1992. abstract
  320. Nordback IH, Hruban RH, Boitnott JK, Pitt HA, Cameron JL. Carcinoma of the body and tail of the pancreas. Am J Surg 164:26-31, 1992. abstract
  321. Nordback IH, Hruban RH, Cameron JL. Second primary lesions in the biliary tree after successful resection of ampullary carcinoma. Surgery 112(1), 1992. abstract
  322. Pitt HA, Grace PA. The role of resection in the management of pancreatic cancer. In: Burns GP, Bank S, eds. Disorders of the Pancreas: Current Issues in Diagnosis and Management. New York, McGraw-Hill, Inc., 383-413, 1992.
  323. Talamini MA, Pitt HA, Hruban RH, Boitnott JK, Coleman J, Cameron JL. Spectrum of cystic tumors of the pancreas. Am J Surg 163:117-124, 1992. abstract
  324. Allison DC, Bose KK, Hruban RH, Piantadosi S, Dooley WC, Boitnott JK, Cameron JL. Pancreatic cancer cell DNA content correlates with long-term survival after pancreatoduodenectomy. Ann Surg 214:648-656, 1991. abstract
  325. Cameron JL, Crist DW, Sitzmann JV, Hruban RH, Boitnott JK, Seidler AJ, Coleman J. Factors influencing survival following pancreaticoduodenectomy for pancreatic cancer. Am J Surg 161:120-124, 1991. abstract
  326. Kern SE, Kinzler KW, Baker SJ, Nigro JM, Rotter V, Levine AJ, Friedman P, Prives C, Vogelstein B. Abnormal DNA-binding of mutant p53 proteins in vitro. Oncogene 1991; 6:131-136. abstract
  327. Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B. Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708-1711, 1991. abstract
  328. McGuire GF, Pitt HA, Lillemoe KD, Niederhuber JE, Yeo CJ, Cameron JL. Reoperative surgery for periampullary adenocarcinoma. Arch Surg 126:1205-1212, 1991. abstract
  329. Pitt HA, Grace PA. Pylorus preserving resection of the pancreas. In: Neoptolemos JP, ed. Clinical Gastroenterology. Vol 4. London: Beilliere Tindell 4:917-30, 1991.
  330. >Dooley WC, Allison DC, Bose K. New assay for genetic diversity of tumor cells. Cell Tiss Kinet 22:4, 1990.
  331. >Dooley W, Lin P, Allison D. Mitotic events and kinetic diversity in tumor cells. Cell Prolif 24:410, 1990.
  332. Dooley WC, Cameron JL, Pitt HA, Lillemoe KD, Yeu NC, Venbrux AC. Is preoperative arteriography useful in patients with periampullary tumors? Ann Surg 211:649-655, l990. abstract
  333. Zinner MJ, Shurbaji MS, Cameron JL. Solid and papillary epithelial neoplasms of the pancreas. Surgery 108:475-80, 1990. abstract
  334. Cameron JL. Carcinoma of the pancreas: are we making progress? Maryland Med J 39(4), 1990. abstract
  335. Lillemoe KD, Pitt HA, Kaufman SL, Cameron JL. Acute cholecystitis occurring as a complication of percutaneous transhepatic drainage. Surg Gynecol Obstet 168:348-352, l989. abstract
  336. Trerotola SO, Jones B, Crist DW, Cameron JL. Pylorus-preserving Whipple pancreaticoduodenectomy: postoperative evaluation. Radiology 171;735-738, 1989. abstract
  337. Cameron JL. Current status of the Whipple operative for periampullary carcinoma. Surg Rounds 77-87, 1988.
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