The Sol Goldman Pancreatic Cancer Research Center

Advances and Discoveries Made at Johns Hopkins

Defining a Window of Opportunity for Early Detection
It is hard to imagine going back in time to determine the life history of a cancer, but Dr. Yachida and colleagues have done just that. By sequencing multiple different tumors from the same patient, they were able to estimate when and where each of the genetic changes they identified occurred. Surprisingly, they found that it can take many years for an invasive pancreatic cancer to develop. This study is important because it suggests that there is a large window of opportunity for the early detection of pancreatic cancer.

Yachida S, Jones S, Bozic I, Antal t, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 467:1114-7, 2010.